The 'nottuff3' package in the npm ecosystem is identified as containing malicious code that compromises the entire host system. Installation or execution of this package grants an attacker full control over the affected computer. Due to the extent of compromise, simply uninstalling the package is insufficient to ensure system integrity, as additional malicious components may persist. The advisory recommends immediate secret and key rotation from a separate, uncompromised system to mitigate potential damage.

Full system compromise occurs upon installation or execution of the 'nottuff3' package. All secrets and keys stored on the affected machine are at risk of exposure and must be rotated. The presence of this package indicates that an attacker may have persistent access, and removal of the package alone does not guarantee remediation.

Remove the 'nottuff3' package immediately. Rotate all secrets and keys stored on the affected computer from a different, trusted machine. Due to the potential for persistent malicious software beyond the package itself, consider a full system rebuild or forensic analysis to ensure complete remediation.