CVE-2025-21381: Microsoft 365 Apps for Enterprise · Untrusted Pointer Dereference
Affects Microsoft 365 Apps for EnterpriseSource CVE Database V5
Not known to be exploited · CVSS 7.8 High.
Data as of 25 Oct 2026, 19:02 UTC
- EPSS
- 1.1% chance of exploitation in 30 days – higher than 66% of CVEsExploit Prediction Scoring System: the likelihood attackers will use this flaw soon.
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H/E:U/RL:O/RC:CExploitation evidence
Disclosed: evidence found.
CVE published 11 Feb 2025
Detectable: no evidence on record.
No public nuclei template indexed
Weaponised: no evidence on record.
No public exploit code indexed in Metasploit or Exploit-DB
Exploited in the wildExploited: no evidence on record.
Not in CISA KEV and no source reports exploitation
Observed by OffSeq MirageSeen by Mirage: no evidence on record.
No attack traffic recorded by OffSeq Mirage sensors
A missing step is not evidence of safety. Sources: cve.org (opens in a new tab), the Metasploit, Exploit-DB and nuclei-templates index as of 2026-10-25.
What to do
Affected software
| Product | Affected | Fixed in |
|---|---|---|
| Microsoft Microsoft 365 Apps for Enterprise | Affected
| Fixed in– |
AI-suggested
1. Monitor Microsoft security advisories closely and apply patches immediately once released for Microsoft 365 Apps for Enterprise, specifically targeting Excel version 16.0.1. 2. Implement strict email and file filtering to block or quarantine suspicious Excel files, especially those from unknown or untrusted sources. 3. Employ application control and sandboxing techniques to restrict execution of untrusted Office documents. 4. Educate users about the risks of opening unsolicited or unexpected Excel files and encourage verification of file sources. 5. Use endpoint detection and response (EDR) solutions to identify and respond to suspicious behaviors related to Excel processes. 6. Enforce the principle of least privilege on user accounts to limit the impact of potential exploitation. 7. Disable or restrict macros and other potentially dangerous Excel features unless explicitly required and verified. 8. Consider network segmentation to isolate critical systems that handle sensitive Excel files from general user environments. 9. Regularly back up critical data and verify restoration procedures to mitigate ransomware or destructive attack scenarios stemming from exploitation.
Description
Microsoft Excel Remote Code Execution Vulnerability