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VulnerabilityPublished Updated

CVE-2025-65270: ClinCapture EDC · Reflected Cross-site Scripting (XSS)

Source CVE Database V5

0

Not known to be exploited · CVSS 6.1 Medium.

Data as of 26 Oct 2026, 08:30 UTC

CVSS 3.1 base score
6.1Medium
How severe the flaw is on the 0–10 CVSS scale.
EPSS
0.2% chance of exploitation in 30 days – higher than 21% of CVEsExploit Prediction Scoring System: the likelihood attackers will use this flaw soon.
CVSS:3.1/AV:N/AC:L/PR:N/UI:R/S:C/C:L/I:L/A:N

Exploitation evidence

  1. Disclosed: evidence found.

    CVE published 22 Dec 2025

  2. Detectable: no evidence on record.

    No public nuclei template indexed

  3. Weaponised: no evidence on record.

    No public exploit code indexed in Metasploit or Exploit-DB

  4. Exploited in the wild: no evidence on record.

    Not in CISA KEV and no source reports exploitation

  5. Observed by OffSeq Mirage: no evidence on record.

    No attack traffic recorded by OffSeq Mirage sensors

A missing step is not evidence of safety. Sources: cve.org (opens in a new tab), the Metasploit, Exploit-DB and nuclei-templates index as of 26 Oct 2026.

What to do

AI-suggested

To mitigate this vulnerability, organizations should immediately implement strict input validation and output encoding on all user-supplied data within ClinCapture EDC interfaces. Employ Content Security Policy (CSP) headers to restrict the execution of unauthorized scripts in browsers. Conduct thorough code reviews focusing on areas where user input is reflected in responses. Since no patches are currently available, consider deploying web application firewalls (WAFs) with rules to detect and block XSS attack patterns targeting ClinCapture. Educate users about the risks of clicking unsolicited links and implement multi-factor authentication to reduce the impact of credential theft. Monitor logs for unusual activity indicative of XSS exploitation attempts. Engage with the vendor for timely updates and patches. Finally, isolate clinical trial systems from general networks and restrict access to trusted personnel to minimize exposure.

Description

Reflected cross-site scripting (XSS) vulnerability in ClinCapture EDC 3.0 and 2.2.3, allowing an unauthenticated remote attacker to execute JavaScript code in the context of the victim's browser.

References

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