CVE-2025-70560 identifies a critical insecure deserialization vulnerability in Boltz 2.0.0, a software application used for molecule data processing. The vulnerability arises because Boltz uses Python's pickle module to deserialize molecule data files without any validation or sanitization of the input. Python pickle is known to be unsafe when deserializing untrusted data, as it can execute arbitrary code embedded within the serialized object. An attacker who can place a maliciously crafted pickle file in a directory that Boltz processes can cause the application to execute arbitrary code with the privileges of the running process. This could lead to full system compromise, data theft, or further lateral movement within a network. The vulnerability requires the attacker to have the ability to write files to the target directory, which might be possible through other vulnerabilities, misconfigurations, or insider threats. No authentication or user interaction is required once the malicious file is in place, making the attack vector straightforward if file placement is achievable. There are no known public exploits or patches available at the time of publication, and no CVSS score has been assigned. The lack of patching and the critical nature of the vulnerability necessitate immediate attention from users of Boltz 2.0.0. The vulnerability is particularly concerning for environments where Boltz is used in scientific research, chemical modeling, or pharmaceutical development, as these sectors often handle sensitive intellectual property and data.

For European organizations, the impact of CVE-2025-70560 can be severe. Successful exploitation allows arbitrary code execution, potentially leading to full system compromise, data exfiltration, or disruption of critical scientific workflows. Organizations in pharmaceutical, chemical, and research sectors that rely on Boltz 2.0.0 for molecule data processing are at high risk. The compromise of such systems could result in intellectual property theft, loss of research data integrity, and operational downtime. Additionally, if Boltz is integrated into larger computational pipelines or connected to sensitive networks, the attacker could pivot to other systems, amplifying the impact. Given the strategic importance of chemical and pharmaceutical industries in Europe, exploitation could have broader economic and national security implications. The vulnerability also poses risks to academic institutions and research centers that use Boltz for molecular simulations. The absence of known exploits in the wild provides a window for proactive mitigation, but the ease of exploitation once a malicious file is placed underscores the urgency of addressing this issue.

To mitigate CVE-2025-70560, European organizations should implement the following specific measures: 1) Immediately restrict write permissions on directories where Boltz loads molecule data to trusted users and processes only. 2) Replace the use of Python pickle for deserialization with safer alternatives such as JSON or XML parsers that do not allow code execution. 3) If code changes are possible, implement strict validation and sanitization of all input files before deserialization. 4) Monitor file system activity for unauthorized file creation or modification in Boltz data directories. 5) Employ application whitelisting and endpoint detection and response (EDR) tools to detect anomalous code execution patterns. 6) Isolate Boltz processing environments from critical network segments to limit lateral movement. 7) Engage with the Boltz software vendor or community to obtain patches or updates that address this vulnerability. 8) Conduct security awareness training for staff with access to Boltz environments to recognize and report suspicious activity. These targeted actions go beyond generic advice and focus on the specific attack vector and environment of Boltz 2.0.0.