CVE-2025-62216 is a use-after-free vulnerability classified under CWE-416 affecting Microsoft 365 Apps for Enterprise version 16.0.1. This vulnerability arises when the application improperly manages memory, allowing an attacker to execute code locally by exploiting freed memory that is still referenced. The flaw enables an unauthorized attacker to run arbitrary code on the affected system, potentially leading to full system compromise. Exploitation requires local access and user interaction, such as opening a malicious file or triggering a crafted action within the Office app, but does not require prior privileges or authentication. The vulnerability impacts confidentiality, integrity, and availability, as it can lead to arbitrary code execution with the same privileges as the user. Although no known exploits are currently in the wild, the high CVSS score of 7.8 indicates significant risk. No patches have been released yet, increasing the urgency for organizations to implement interim mitigations. The vulnerability is particularly critical given the widespread use of Microsoft 365 Apps in enterprise environments, making it a valuable target for attackers aiming to compromise corporate networks through local vectors.

For European organizations, this vulnerability poses a significant risk due to the widespread adoption of Microsoft 365 Apps across business, government, and critical infrastructure sectors. Successful exploitation could lead to unauthorized code execution, enabling attackers to steal sensitive data, disrupt operations, or establish persistent footholds within networks. The local access requirement limits remote exploitation but does not eliminate risk, especially in environments where endpoint security is weak or where users may be tricked into opening malicious documents. The high impact on confidentiality, integrity, and availability means that data breaches, ransomware deployment, or sabotage are plausible outcomes. Given the lack of patches and known exploits, organizations face a window of vulnerability that could be exploited by sophisticated threat actors targeting European entities with strategic or economic value. The threat is amplified in sectors with high regulatory requirements for data protection, such as finance, healthcare, and government.

Until an official patch is released, European organizations should implement strict endpoint security controls, including application whitelisting and enhanced monitoring for suspicious Office document activity. User education is critical to reduce the risk of social engineering attacks that could trigger exploitation. Restricting local access to sensitive systems and enforcing the principle of least privilege can limit the attack surface. Employing advanced endpoint detection and response (EDR) solutions to detect anomalous behavior related to memory corruption or code execution attempts is recommended. Organizations should also prepare for rapid deployment of patches once available by maintaining up-to-date asset inventories and testing procedures. Network segmentation can help contain potential compromises. Additionally, disabling or restricting macros and other potentially dangerous Office features can reduce exploitation vectors. Regular backups and incident response readiness will mitigate impact if exploitation occurs.